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Best Creams To Repair Crepey Skin

I found a couple creams that actually work

What causes crepey, loose skin skin? (READ THIS, IT'S IMPORTANT TO UNDERSTAND)

Sun damage is the most common cause of crepey skin, but it certainly isn't the only cause. Crepey skin can also result from aging, a lack of moisture, excessive weight loss, or any combination of these.

The ultraviolet light in the sun’s rays break down collagen and elastin in skin that help it stay tight and wrinkle-free. Once these fibers break down, the skin can loosen, thin, and wrinkle.

Age is also a factor. You produce less collagen and elastin — the fibers that help your skin look supple and smooth — the older you get. Pollution, stress, and smoking cigarettes all take a toll on skin over your lifetime and can contribute to visible signs of aging.

As you age, your skin produces less oil than it did when you were younger. These oils create an important lipid barrier that protects your skin and helps seal in moisture. Hormonal changes can also lead to drier skin and less natural oil production. 
Here is how I went about this and my research that supports it:

Crepey Skin: Can also result from aging, a lack of moisture, excessive weight loss, or any combination of these. The ultraviolet light in the sun's rays break down collagen and elastin in skin that help it stay tight and wrinkle-free. FOR THIS YOU NEED IDEBENONE, HYALURONIC ACID & RETINOL

Loose Saggy Skin: The deterioration or reduction of collagen and elastin in the dermis the of saggy skin. TO FIX THIS YOU NEED RETINOL & COLLAGEN

Wrinkles & Fine Lines: Ultraviolet radiation, which speeds the natural aging process, is the primary cause of early wrinkling. Exposure to UV light breaks down your skin's connective tissue — collagen and elastin fibers, which lie in the deeper layer of skin (dermis). TO FIX THIS YOU NEED A POWERFUL ANTIOXIDANT, IDEBENONE HAS BEEN SHOWN TO BE MOST EFFECTIVE AT THIS

What You Need Is A Liposomal Cream

A liposome is a tiny bubble (vesicle), made out of the same material as a cell membrane. Liposomes can be filled with nutrients, and used to deliver them through the skin's barrier due to their low molecular weight. Membranes are usually made of phospholipids, which are molecules that have a head group and a tail group.

A liposomal cream BONDS TO EVERY LAYER OF SKIN ON ITS WAY DOWN. So more of the anti aging ingredients make it into your cells than a standard cream. 

Topical creams are just that (they only treat the top) - the problem is aging skin cells need to be treated directly. That means your cream MUST have a low molecular weight and be encapsulated into a LIPOSOME.

What To Look Out For, In An Effective Crepey Skin Repair Cream?

  • It should contain at least two of these active ingredients: Idebenone, Hyaluronic Acid, Retinol, Collagen and natural amino acids.
  • It should be liposomal and absorb into your cells directly, topical creams are a waste of money.***
  • It should contain Hyaluronic Acid to deliver a moisture boost and plump the tired skin
  • ​It MUST have Idebenone - it's the most powerful antioxidant known to science.
  • ​It MUST have Retinol - This is the ultimate in skin firming ingredients, very effective.

Idebenone Is The Real Key To Fixing Crepey Skin

Idebenone is considered to be one of the top-rated anti-aging drugs due to its ability to rejuvenate and preserve dying tissue mitochondria. Idebenone is so highly respected that it is used as an organ preservative when transporting live organs for organ transplant procedures (2 scientific references below). It works because it has two functions. 

First, it scavenges the body for free radicals (caused by old age, smoking, pollution, alcohol, sun damage . . . ). Only when delivered via liposome idebenone can regulate and normalizes energy production in mitochondria of the cell. Topical creams are useless for this. 

Once expressed into the cell via liposome the idebenone can diminish the appearance of fine lines and wrinkles as it reverses UVA/UVB photodamage to skin cells (scientific reference below) It found a 26% reduction in skin roughness/dryness was observed, a 37% increase in skin hydration, a 29% reduction in fine lines/wrinkles, and a 33% improvement in overall global assessment of photodamaged skin. 

In recent studies, Idebenone was shown EXTREMELY effective in treating sun damaged (crepey) skin.
Our Sources:
Author Lynette Fredrics

After my years of working in a fitness center, I constantly hear people talking about different products they use to help them look and feel their best, along with other supplements they use to help improve heart health and fuel their body's weight loss.

Now I work as a beauty review specialist, alongside my team of experts. We conduct extensive research on products and in many cases use them ourselves when applicable. 

I started blogging like this so I can share my knowledge and experience with the world and hopefully help you save some time and money when shopping for the top beauty products.

#1.Hygieia Crepe Repair Cream (Liposomal)

Only Need One Cream vs. An Entire Kit Needed
Contains Encapsulated Retinol + More
Can Be Used On Any Body Part
60 Day Money Back Guarantee
Offers Free Shipping To Everyone

Pros

  • ​Contains Idebenone
  • ​Contains Retinol
  • ​Hyaluronic Acid
  • ​Contains Amino Acids
  • ​All Natural Ingredients
  • ​No Unnecessary Fillers
  • 60-day Money-back Guarantee
  • ​No Surprise Automatic Rebilling
  • ​US Customer Support
  • ​Better Value Than Our Second Pick

Cons

  • ​Shipping took an extra day

The Bottom Line

Unlike other lower-quality neck firming creams we reviewed, this cream TREATS THE SKIN MITOCHONDRIA DIRECTLY, WHICH IS THE ACTUAL CAUSE OF CREPEY LOOSE SKIN. THIS CREAM WILL FIRM YOUR SKIN FAST.

A deeper look at the active ingredients contained in it demonstrates that Idebenone is an ingredient frequently included in products designed to stimulate collagen production and synthesis, thus improving the skin’s tensile strength and its ability to resist stretching and sagging. 

This company has over 1600 verified reviews and offers a 60 day money back guarantee. That gave me the confidence to try it, and boy am I glad I did.

This cream checks all the boxes for us, its liposomal, it has Idebenone & it also has Hyaluronic Acid & Encapsulated Retinol which is well known for skin firming and treatment of crepey skin.

If you're looking for a crepey skin treatment thats affordable and you can do at home, this is the cream for you. Read their reviews...they're nothing short of amazing.

We also appreciate the fact that this Neck Firming & Crepe Correcting Cream is made with non-GMO ingredients, is paraben free, and is formulated for all skin types here in the USA.

The company recently doubled the size of their Jars (from 2oz to 4oz) for the same price - which I find refreshing in a world where every other company is trying to stick you with inflation this one is trying to helps its customers get more value.

This cream is less expensive than the competition because you only need a SINGLE CREAM vs an entire kit to be effective.

#2 - Crepe Erase

Pros

  • Popular Brand

Cons

  • ​Bundle of 5 different products
  • ​No Idebenone
  • ​No Hyaluronic Acid
  • No Liposomal

The bottom line

Crepe erase is a popular TV brand who runs large scale ads on popular networks. They have been around a long time and have a large base of customers due to their wide exposure on the mainstream media.

At this time they are promoting a bundle of 7 products to treat crepey skin for a discounted price of $59 (roughly $10 per product) - in my experience nothing good comes that cheap. From the looks of it, they are also only sample sizes, that won't last very long if you are trying to resolve crepey skin on your arms or legs.

They do however have many good reviews and success stories, they are pretty vague on their ingredients and the science behind their creams however and it seems to me like they want you to trust them because they paid celebrities to promote their products.


Best Skin Reviews does not claim to, or have any right to, any of the Trademarks relating to Balance of Nature and those which may be displayed on this page.

Results are based on our system and do not necessarily reflect typical results from the use of these products. Rankings are not intended to measure the potential efficacy of each product, and any discussion of the ingredients is for informational purposes only. Please visit product websites for more information.

3. Strivectin®

Pros

  • ​Nice package

Cons

  • ​More expensive that top pick
  • ​No Idebenone
  • ​No Hyaluronic Acid
  • ​Very Expensive

The Bottom Line

Strivectin® TL Advanced Tightening Neck Cream Plus contains a large number of ingredients, including peptides, ceramides, hyaluronic acid, and three ingredient complexes that are unique to Strivectin® products. According to the manufacturer’s website, Strivectin®’s neck cream was formulated to provide an instantaneous tightening effect as well as a noticeable improvement in skin’s appearance overtime.

Our research indicates that Strivectin®’s neck cream also contains Nia-114, which appears to be their own blend of vitamin B, which is added to many of their skin care products and used to improve hydration of the skin. The hyaluronic acid and ceramides in the product also boost water retention and improve skin hydration.

Several customers provided feedback that led us to believe that the product might not be the best for everyone, including information that led us to believe that this neck firming cream might be a better choice for those with dry skin – not those with normal or excessive oily skin.

We also found the product to contain over 40 different ingredients, including things like Sorbitan Laurate, a food additive, undefined fragrances and perfumes, and Ethylene/Acrylic Acid Copolymer – for which we found research indicating potential toxicity, depending on the concentration.

Considering the vast number of ingredients, and limited research supporting effectiveness available for some, our research team felt other neck firming options included in this review were a better option, both for quality and value.

Our reviewers found the company’s website contained a lot of information about the product; however, when reviewing the product itself, although they found it to have a smooth, non-greasy texture, it is a bit more expensive then other creams in this review, especially when considering the mixed reviews provided by customers.

Available for 1.7 fl oz jar for $95, PRODUCT works out to be $56 per fluid ounce and is second highest ranked product in this review.

* Results are based on our system and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.


1. studies 
QSA 10 (idebenone) supplementation of organ preservation solutions prevents oxygen radical-mediated injury of hepatic microsomes E Wieland 1, E Schütz, V W Armstrong, B Ringe, M Oellerich PMID: 7879165

Similar articles Idebenone protects hepatic microsomes against oxygen radical-mediated damage in organ preservation solutions Wieland E, Schütz E, Armstrong VW, Küthe F, Heller C, Oellerich M. Transplantation. 1995 Sep 15;60(5):444-51. doi: 10.1097/00007890-199509000-00007. PMID: 7676491

2. Second scientific reference Idebenone: Novel Strategies to Improve Its Systemic and Local Efficacy

Lucia Montenegro 1, Rita Turnaturi 2, Carmela Parenti 3, Lorella Pasquinucci 4
Affiliations expand
PMID: 29401722 PMCID: PMC5853719 DOI: 10.3390/nano8020087
Free PMC article
Abstract

The key role of antioxidants in treating and preventing many systemic and topical diseases is well recognized. One of the most potent antioxidants available for pharmaceutical and cosmetic use is Idebenone (IDE), a synthetic analogue of Coenzyme Q10. Unfortunately, IDE's unfavorable physicochemical properties such as poor water solubility and high lipophilicity impair its bioavailability after oral and topical administration and prevent its parenteral use. In recent decades, many strategies have been proposed to improve IDE effectiveness in the treatment of neurodegenerative diseases and skin disorders. After a brief description of IDE potential therapeutic applications and its pharmacokinetic and pharmacodynamic profile, this review will focus on the different approaches investigated to overcome IDE drawbacks, such as IDE incorporation into different types of delivery systems (liposomes, cyclodextrins, microemulsions, self-micro-emulsifying drug delivery systems, lipid-based nanoparticles, polymeric nanoparticles) and IDE chemical modification. The results of these studies will be illustrated with emphasis on the most innovative strategies and their future perspectives.



Tolerability and improved protective action of idebenone-loaded pegylated liposomes on ethanol-induced injury in primary cortical astrocytes

Donatella Paolino 1, Michelangelo Iannone, Venera Cardile, Marcella Renis, Giovanni Puglisi, Domenicantonio Rotiroti, Massimo Fresta
Affiliations expand
PMID: 15176069 DOI: 10.1002/jps.20088
Abstract

The potential therapeutic advantages of the encapsulation of idebenone within pegylated liposomes were investigated in vitro on primary cortical astrocytes of rats. In particular, both the concentration-dependent effects and the therapeutic effectiveness toward excitotoxic injury, elicited by chronic treatment with ethanol (100 microM) for 12 days, were evaluated. The following parameters were taken into consideration to assay free or liposomally entrapped idebenone: lactic dehydrogenase release, respiratory capacity measured by tetrazolium salt conversion, glutamine synthetase, and the levels of constitutive and inducible 70-kDa heat shock proteins. To evaluate the effects on astrocytes, three different drug concentrations were used (0.5 microM, 5 microM, and 50 microM). At the highest concentration used (50 microM), a toxic effect of the free and liposomally entrapped drug was observed. Toxic effects seem to be due to a cellular membrane perturbation, as demonstrated by (45)Ca(2+) permeation. The therapeutic effect of free or liposomally entrapped idebenone on ethanol-induced injury of primary cortical astrocytes was evaluated as a function of the drug concentration. The drug liposome formulation was much more effective than the free drug in counteracting the ethanol-induced damage in astrocytes, i.e., 10-times-lower doses of liposomally entrapped idebenone are able to provide a greater protective action than the free drug. The improved action of idebenone-loaded liposomes is probably due to the greater drug bioavailability at the cellular level.

Copyright 2004 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 93:1815-1827, 2004

Differential Scanning Calorimetry Analyses of Idebenone-Loaded Solid Lipid Nanoparticles Interactions with a Model of Bio-Membrane: A Comparison with In Vitro Skin Permeation Data

Lucia Montenegro 1, Francesco Castelli 2, Maria Grazia Sarpietro 3
Affiliations expand
PMID: 30558360 PMCID: PMC6316718 DOI: 10.3390/ph11040138
Free PMC article
Abstract

Differential scanning calorimetry (DSC) has emerged as a helpful technique both to characterize drug delivery systems and to study their interactions with bio-membranes. In this work, we compared idebenone (IDE)-loaded solid lipid nanoparticle (SLN) interactions with bio-membranes assessed by DSC with previous in vitro skin penetration data to evaluate the feasibility of predicting IDE skin penetration using DSC analyses. In vitro interactions experiments were performed using multi-lamellar liposomes as a model of bio-membrane. Enthalpy changes (ΔH) and transition temperature (Tm) were assessed during nine repeated DSC scans to evaluate IDE-loaded SLN⁻bio-membrane interactions over time. Analyzing ΔH and Tm values for each scan, we observed that the difference of ΔH and Tm values between the first and the last scan seemed to be related to SLN ability to locate IDE in the epidermis and in the stratum corneum, respectively. Therefore, the results of this study suggest the possibility of qualitatively predicting in vitro IDE skin penetration from IDE-loaded SLN utilizing the calorimetric parameters obtained from interaction experiments between the carriers under investigation and a model of bio-membrane.



Clinical efficacy assessment in photodamaged skin of 0.5% and 1.0% idebenone

D H McDaniel 1, B A Neudecker, J C DiNardo, J A Lewis 2nd, H I Maibach
Affiliations expand
PMID: 17129261 DOI: 10.1111/j.1473-2165.2005.00305.x
Abstract

Idebenone is an antioxidant lower molecular weight analogue of coenzyme Q10. Previously, idebenone was shown to be a very effective antioxidant in its ability to protect against cell damage from oxidative stress in a variety of biochemical, cell biological, and in vivo methods, including its ability to suppress sunburn cell (SBC) formation in living skin. However, no clinical studies have been previously conducted to establish the efficacy of idebenone in a topical skincare formulation for the treatment of photodamaged skin. In this nonvehicle control study, 0.5% and 1.0% idebenone commercial formulations were evaluated in a clinical trial for topical safety and efficacy in photodamaged skin. Forty-one female subjects, aged 30-65, with moderate photodamaged skin were randomized to use a blind labelled (either 0.5% or 1.0% idebenone in otherwise identical lotion bases) skincare preparation twice daily for six weeks. Blinded expert grader assessments for skin roughness/dryness, fine lines/wrinkles, and global improvement in photodamage were performed at baseline, three weeks and six weeks. Electrical conductance readings for skin surface hydration and 35 mm digital photography were made at baseline after six weeks. Punch biopsies were taken from randomly selected subjects, baseline and after six weeks, and stained for certain antibodies (interleukin IL-6, interleukin IL-1b, matrixmetalloproteinase MMP-1, collagen I) using immunofluorescence microscopy. After six weeks' use of the 1.0% idebenone formula, a 26% reduction in skin roughness/dryness was observed, a 37% increase in skin hydration, a 29% reduction in fine lines/wrinkles, and a 33% improvement in overall global assessment of photodamaged skin. For the 0.5% idebenone formulation, a 23% reduction in skin roughness/dryness was observed, a 37% increase in skin hydration, a 27% reduction in fine lines/wrinkles, and a 30% improvement in overall global assessment of photodamaged skin. The immunofluorescence staining revealed a decrease in IL-1b, IL-6, and MMP-1 and an increase in collagen I for both concentrations.

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