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Akt/PKB signaling pathway. The Akt signaling pathway or PI3K-Akt signaling pathway is a signal transduction pathway that promotes survival and growth in response to extracellular signals. Key proteins involved are PI3K ( phosphatidylinositol 3-kinase) and Akt ( protein kinase B ). Initial stimulation by one of the growth factors causes ...
Crystal structure of Akt-2-inhibitor complexes. [2] Protein kinase B ( PKB ), also known as Akt, is the collective name of a set of three serine/threonine-specific protein kinases that play key roles in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription, and cell migration .
according to International Monetary Fund estimates [n 1] [1] Countries by nominal GDP in 2019 [n 2] > $20 trillion. $10–20 trillion. $5–10 trillion. $1–5 trillion. $750 billion – $1 trillion. $500–750 billion. $250–500 billion.
Printed circuit board of a DVD player. Part of a 1984 Sinclair ZX Spectrum computer board, a printed circuit board, showing the conductive traces, the through-hole paths to the other surface, and some electronic components mounted using through-hole mounting. A printed circuit board ( PCB ), also called printed wiring board ( PWB ), is a medium ...
AKT1. RAC (Rho family)-alpha serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT1 gene. This enzyme belongs to the AKT subfamily of serine/threonine kinases that contain SH2 (Src homology 2-like) protein domains. [5] It is commonly referred to as PKB, or by both names as "Akt/PKB".
System information modelling ( SIM) is the process of modelling complex connected systems. System information models are digital representations of connected systems, such as electrical instrumentation and control, power, and communication systems. The objects modelled in a SIM have a 1:1 relationship with the objects in the physical system.
Activating transcription factor. Activating transcription factor, ATF, is a group of bZIP transcription factors, which act as homodimers or heterodimers with a range of other bZIP factors. [1] First, they have been described as members of the CREB/ATF family, [2] whereas it turned out later that some of them might be more similar to AP-1 -like ...
Transcription factor II D ( TFIID) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. RNA polymerase II holoenzyme is a form of eukaryotic RNA polymerase II that is recruited to the promoters of protein -coding genes in living cells. It consists of RNA polymerase II, a subset of general ...
PRKACB. cAMP-dependent protein kinase catalytic subunit beta is an enzyme that in humans is encoded by the PRKACB gene. [5] cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the protein kinase A (PKA), which transduces the signal through phosphorylation of different target proteins.
Function. This gene encodes a cytoplasmic protein tyrosine kinase that is involved in calcium-induced regulation of ion channels and activation of the MAP kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and ...