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Moderate anemia, splenomegaly, and hepatomegaly. Binucleate and rare multinucleate polychromatic erythroblasts. 224100: SEC23B: 20p11.2 Type III (CDAN3) Mild anemia and retinal degeneration. Giant multinucleated erythroblasts. 105600: KIF23: 15q21 Type IV (CDAN4) Severe anemia at birth. 613673: KLF1: 19p13.13-p13.12
Congenital hemolytic anemia (CHA) is a diverse group of rare hereditary conditions marked by decreased life expectancy and premature removal of erythrocytes from blood flow. Defects in erythrocyte membrane proteins and red cell enzyme metabolism, as well as changes at the level of erythrocyte precursors, lead to impaired bone marrow erythropoiesis.
Gray baby syndrome. Gray baby syndrome (also termed gray syndrome or grey syndrome) is a rare but serious, even fatal, side effect that occurs in newborn infants (especially premature babies) following the accumulation of the antibiotic chloramphenicol. [1] Chloramphenicol is a broad-spectrum antibiotic that has been used to treat a variety of ...
Evans syndrome. Evans syndrome is an autoimmune disease in which an individual's immune system attacks their own red blood cells and platelets, the syndrome can include immune neutropenia. [1] [2] These immune cytopenias may occur simultaneously or sequentially. [1] [3]
Yellowish skin, dark urine, shortness of breath: Complications: Anemia, newborn jaundice: Usual onset: Within a few days of a trigger: Causes: Genetic (X-linked recessive) Risk factors: Triggered by infections, certain medication, stress, foods such as fava beans: Diagnostic method: Based on symptoms, blood test, genetic testing
Specialty. Obstetrics. Twin anemia-polycythemia sequence (TAPS) is a chronic type of unbalanced fetal transfusion in monochorionic twins that results in polycythemia in the TAPS recipient and anemia in the TAPS donor due to tiny placental anastomoses. [1] Post-laser TAPS and spontaneous TAPS are the two forms of TAPS.
Types. Early, Classical, Late. Causes. Vitamin K deficiency. Prevention. Vitamin K supplementation after birth. Vitamin K deficiency bleeding ( VKDB) of the newborn, previously known as haemorrhagic disease of the newborn, [1] is a rare form of bleeding disorder that affects newborns and young infants due to low stores of vitamin K at birth. [2 ...
Hemolytic Anemia - MUST NOT be treated with iron; Late onset anemia - Must NOT be treated with iron. Can persist up to 12 weeks after birth. Cause. Mothers who are negative for the Kell 1 antigen develop antibodies after being exposed to red blood cells that are positive for Kell 1.
In ABO hemolytic disease of the newborn (also known as ABO HDN) maternal IgG antibodies with specificity for the ABO blood group system pass through the placenta to the fetal circulation where they can cause hemolysis of fetal red blood cells which can lead to fetal anemia and HDN. In contrast to Rh disease, about half of the cases of ABO HDN ...
Skin tag. A skin tag, or acrochordon ( pl.: acrochorda ), is a small benign tumor that forms primarily in areas where the skin forms creases (or rubs together), such as the neck, armpit and groin. They may also occur on the face, usually on the eyelids. Though tags up to half an inch (12.7 mm) long have been seen, [2] they are typically the ...