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Watchful waiting, chemotherapy, immunotherapy [4] [5] Prognosis. Five-year survival ~88% (US) [3] Frequency. 904,000 (2015) [6] Deaths. 60,700 (2015) [7] Chronic lymphocytic leukemia ( CLL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell ). [2] [8] Early on, there are typically no symptoms. [2]
Richter's transformation (RT), also known as Richter's syndrome, is the conversion of chronic lymphocytic leukemia (CLL) or its variant, small lymphocytic lymphoma (SLL), into a new and more aggressively malignant disease. [1] CLL is the circulation of malignant B lymphocytes with or without the infiltration of these cells into lymphatic or ...
Leukemia ( also spelled leukaemia and pronounced / luːˈkiːmiːə / [1] loo-KEE-mee-ə) is a group of blood cancers that usually begin in the bone marrow and result in high numbers of abnormal blood cells. [9] These blood cells are not fully developed and are called blasts or leukemia cells. [2]
Chlorambucil. Chlorambucil, sold under the brand name Leukeran among others, is a chemotherapy medication used to treat chronic lymphocytic leukemia (CLL), Hodgkin lymphoma, and non-Hodgkin lymphoma. [2] For CLL it is a preferred treatment. [3] It is given by mouth.
Imatinib is a 2- phenyl amino pyrimidine derivative that functions as a specific inhibitor of a number of tyrosine kinase enzymes. It occupies the TK active site, leading to a decrease in activity. There are a large number of TK enzymes in the body, including the insulin receptor.
It acts by depleting normal as well as pathogenic B cells while sparing plasma cells and hematopoietic stem cells, which do not express the CD20 surface antigen. In the United States, rituximab is indicated to treat: non-Hodgkin lymphoma (NHL) chronic lymphocytic leukemia (CLL)
The Call of Cthulhu. Title page of "The Call of Cthulhu" as it appeared in Weird Tales, February 1928. Illustration by Hugh Doak Rankin. [1] " The Call of Cthulhu " is a short story by American writer H. P. Lovecraft. Written in the summer of 1926, it was first published in the pulp magazine Weird Tales in February 1928.
Text. The Call of the Wild at Wikisource. The Call of the Wild is a short adventure novel by Jack London, published in 1903 and set in Yukon, Canada, during the 1890s Klondike Gold Rush, when strong sled dogs were in high demand. The central character of the novel is a dog named Buck. The story opens at a ranch in Santa Clara Valley, California ...
Natural killer cells directly kill senescent cells, and produce cytokines which activate macrophages which remove senescent cells. Natural killer cells can use NKG2D receptors to detect senescent cells, and kill those cells using perforin pore-forming cytolytic protein.
Cytarabine. Cytarabine, also known as cytosine arabinoside ( ara-C ), is a chemotherapy medication used to treat acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), chronic myelogenous leukemia (CML), and non-Hodgkin's lymphoma. [2] It is given by injection into a vein, under the skin, or into the cerebrospinal fluid. [2]