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HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, official symbol HMGCR) is the rate-controlling enzyme (NADH-dependent, EC 1.1.1.88; NADPH-dependent, EC 1.1.1.34) of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids.
An American child during World War II (1943) purchases a can of V8, handing the grocer his ration book.. V8 Vegetable Juice was developed by Frank Constable of Chicago, Illinois, who worked as a contractor for W.G. Peacock (1896–1948), the founder of the New England Products Company, which manufactured individual vegetable juices under the brand name Vege-min since 1933.
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The European Commission approved the following statement regarding Benecol products: "Plant stanol esters have been shown to lower/reduce blood cholesterol.Blood cholesterol lowering may reduce the risk of coronary heart disease" but noted that "there are no studies demonstrating that plant stanol esters have an impact on population-based CHD morbidity and mortality rates".
The Portfolio Diet is a therapeutic plant-based diet created by British researcher David J. Jenkins in 2003 to lower blood cholesterol. [ 1 ] [ 2 ] The diet emphasizes using a portfolio of foods or food components that have been found to associate with cholesterol lowering to enhance this effect.
Unlike the statins, where cholesterol lowering has been proven to reduce risk of cardiovascular diseases (CVD) and overall mortality under well-defined circumstances, the evidence has been inconsistent for phytosterol-enriched foods or supplements to lower risk of CVD, with two reviews indicating no or marginal effect, [23] [4] and another ...
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