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This initial skin lesion typically heals after 3–6 months. After weeks to years, joints and bones may become painful, fatigue may develop, and new skin lesions may appear. [6] The skin of the palms of the hands and the soles of the feet may become thick and break open. The bones (especially those of the nose) may become misshapen.
Calciphylaxis, also known as calcific uremic arteriolopathy (CUA) or “Grey Scale”, is a rare syndrome characterized by painful skin lesions.The pathogenesis of calciphylaxis is unclear but believed to involve calcification of the small blood vessels located within the fatty tissue and deeper layers of the skin, blood clots, and eventual death of skin cells due to lack of blood flow. [1]
Punch biopsy of a skin lesion showing neutrophilic infiltration in the dermis, with no evidence of vasculitis (same patient with Crohn's disease). Acute, tender, erythematous plaques, nodes, pseudovesicles and, occasionally, blisters with an annular or arciform pattern occur on the head, neck, legs, and arms, particularly the back of the hands ...
Linear scleroderma is a type of localised scleroderma [11] which is an autoimmune disease characterized by a line of thickened skin which can affect the bones and muscles underneath it. It most often occurs in the arms, legs, or forehead, and may occur in more than one area. It is also most likely to be on just one side of the body.
Impetigo is a bacterial infection that involves the superficial skin. [2] The most common presentation is yellowish crusts on the face, arms, or legs. [2] Less commonly there may be large blisters which affect the groin or armpits. [2] The lesions may be painful or itchy. [3] Fever is uncommon. [3]
Epidermolytic hyperkeratosis (also known as "Bullous congenital ichthyosiform erythroderma," [7] "Bullous ichthyosiform erythroderma," [8]: 482 or "bullous congenital ichthyosiform erythroderma of Brocq" [9]) is a rare skin disease in the ichthyosis family, affecting around 1 in 250,000 people.
About 10% of cases do not have lesions on the legs but rather present with one or more skin lesions outside of the legs; ~20% of individuals present with cutaneous lesion(s) but on further or later investigation are found to have disease in non-cutaneous sites such as the lymph nodes, visceral organs, bone marrow, and/or, rarely, central ...
For cutaneous diseases, the diagnosis could be dry skin (with flare ups at dry climate), irritant and allergic contact dermatitis (skin lesions), seborrheic dermatitis (skin lesions), atopic dermatitis (scratching, allokinesis, stinging, burning), psoriasis (skin lesions), urticaria (welts/skin swelling).