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In acute lymphoblastic leukemia, lymphoid cell development stops at the lymphoblast (arrow), which are also overproduced. The cancerous cell in ALL is the lymphoblast. Normal lymphoblasts develop into mature, infection-fighting B-cells or T-cells, also called lymphocytes .
Treatment. Watchful waiting, chemotherapy, immunotherapy [4] [5] Prognosis. Five-year survival ~88% (US) [3] Frequency. 904,000 (2015) [6] Deaths. 60,700 (2015) [7] Chronic lymphocytic leukemia ( CLL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell ).
Prognosis and treatment depends on the specific type of lymphoma as well as the stage and grade. Treatment includes radiation and chemotherapy. Early-stage indolent B-cell lymphomas can often be treated with radiation alone, with long-term non-recurrence.
While earlier studies suggested that only very high-count MBL (i.e. >10x10 9 B-cells/L) was associated with a decrease in survival, more recent studies indicate that high-count MBL (i.e. (i.e. >0.5x10 9 B-cells/L) do show a shorter overall survival.
Five-year survival rate is 65% in the United States. [4] In children under 15 in first-world countries, the five-year survival rate is greater than 60% or even 90%, depending on the type of leukemia. [13] In children with acute leukemia who are cancer-free after five years, the cancer is unlikely to return.
About 1-10% of CLL/SLLs develop a Richter's transformation at a rate of 0.5–1% per year. In earlier studies, the transformed disease was reported to be far more aggressive than CLL/SLL with overall median survival times (i.e. times in which 50% of cases remain alive) between 1.1 and 16.3 months.
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