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CRISPR-Cas systems fall into two classes. Class 1 systems use a complex of multiple Cas proteins to degrade foreign nucleic acids. Class 2 systems use a single large Cas protein for the same purpose. Class 1 is divided into types I, III, and IV; class 2 is divided into types II, V, and VI. [82]
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Sticky and Ron, two drug users who received Jimmy McGill's 50 percent off business card, go on a multi-day binge. They purchase numerous bags of cocaine from the Salamanca stash house but the bags get stuck in the drainpipe. The police arrive just before Domingo Molina dislodges the drugs. He is arrested and the police prepare to raid the house.
In finance, a coupon is the interest payment received by a bondholder from the date of issuance until the date of maturity of a bond . Coupons are normally described in terms of the "coupon rate", which is calculated by adding the sum of coupons paid per year and dividing it by the bond's face value. For example, if a bond has a face value of ...
Meanwhile, another unit of the FDA told Janssen in January 1999 that its request a year earlier to extend the label for treatment of the elderly was denied because it had failed to “fully evaluate the safety of [Risperdal] for use” by that population.
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