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Treatment. Watchful waiting, chemotherapy, immunotherapy [4] [5] Prognosis. Five-year survival ~88% (US) [3] Frequency. 904,000 (2015) [6] Deaths. 60,700 (2015) [7] Chronic lymphocytic leukemia ( CLL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell ).
While most cases of ALL occur in children, 80% of deaths from ALL occur in adults. Chronic lymphocytic leukemia (CLL) most often affects adults over the age of 55. It sometimes occurs in younger adults, but it almost never affects children. Two-thirds of affected people are men.
The five-year survival rate is about 35% in people under 60 years old and 10% in people over 60 years old. [3] Older people whose health is too poor for intensive chemotherapy have a typical survival of five to ten months. [3]
Age at diagnosis: children 1–10 years of age are most likely to develop ALL and to be cured of it. Cases in older people are more likely to result from chromosomal abnormalities (e.g., the Philadelphia chromosome) that make treatment more difficult and prognoses poorer.
CLL/SLL is the most common adult leukemia in Western countries, accounting for 1.2% of the new cancers diagnosed each year in the United States. It usually occurs in older adults (median age at diagnosis 70) and follows an indolent course over many years. About 1-10% of CLL/SLLs develop a Richter's transformation at a rate of 0.5–1% per year.
Scemblix is approved in more than 70 countries, including an accelerated approval in the U.S., to treat adults with CML who have previously received two or more standard-of-care treatments.