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As of 2020, up to 48 fusion partners have been cataloged in NSCLC rearrangements, with KIF5B and CCDC6 being the most prevalent. [1] At least 10 different fusion variants have been described for KIF5B-RET, each with different breakpoints within the partner gene, but their clinical impact remains unclear as of 2018. [2]
Patients in the fusion-negative group had different genetic mutation profiles than those in the fusion-positive group. [18] Focusing on the fusion negative population, it was shown that the most fusion-negative tumors were caused by RAS isoform mutations. [18]
Image fusion methods can be broadly classified into two groups – spatial domain fusion and transform domain fusion. The fusion methods such as averaging, Brovey method, principal component analysis and IHS based methods fall under spatial domain approaches. Another important spatial domain fusion method is the high-pass filtering based technique.
Anaplastic lymphoma kinase (ALK) was originally discovered in 1994 [5] [7] in anaplastic large-cell lymphoma (ALCL) cells. ALCL is caused by a (2;5)(p23:q35) chromosomal translocation that generates the fusion protein NPM-ALK, in which the kinase domain of ALK is fused to the amino-terminal part of the nucleophosmin (NPM) protein.
The study found that these tumor cells expressed: the EWSR1-CREB3L1 fusion gene in 7 cases, the EWSR1-CREB3L2 fusion gene in 1 case, the FUS-CREB3L2 fusion gene in 3 cases, the YAP1-KMT2A fusion gene in 2 cases, other types of rearrangements (e.g. deletions) in one or both of their EWSR1 genes in 12 cases, and inconclusive results in 1 case. [8]
A type of infusion pump, manufactured by Fresenius. An infusion pump infuses fluids, medication or nutrients into a patient's circulatory system.It is generally used intravenously, although subcutaneous, arterial and epidural infusions are occasionally used.