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History. Phencyclidine (PCP) is believed to be the first arylcyclohexylamine with recognized anesthetic properties, but several arylcyclohexylamines were described before PCP in the scientific literature, beginning with PCA (1-phenylcyclohexan-1-amine) the synthesis of which was first published in 1907. PCP itself was discovered in 1926 but not ...
Cyclohexylamine is used as an intermediate in synthesis of other organic compounds. It is the precursor to sulfenamide -based reagents used as accelerators for vulcanization. It is a building block for pharmaceuticals (e.g., mucolytics, analgesics, and bronchodilators ).
Eticyclidine ( PCE, CI-400) is a dissociative anesthetic drug with hallucinogenic effects. It is similar in effects to phencyclidine but is slightly more potent. PCE was developed by Parke-Davis in the 1970s and evaluated for anesthetic potential under the code name CI-400, [2] but research into PCE was not continued after the development of ...
The pyrolysis of N,N-dimethyl-2-phenylcyclohexylamine-N-oxide shows how conformational effects and the stability of the transition state affect product composition for cyclic substrates. In the trans isomer, there are two cis-β-hydrogens that can eliminate. The major product is the alkene that is in conjugation with the phenyl ring, presumably ...
Retrosynthetic analysis is a technique for solving problems in the planning of organic syntheses. This is achieved by transforming a target molecule into simpler precursor structures regardless of any potential reactivity/interaction with reagents. Each precursor material is examined using the same method.
Synthesis. Dicyclohexylamine, as a mixture with cyclohexylamine, is prepared by the catalytic hydrogenation of aniline (phenylamine), with a catalyst of ruthenium and/or palladium. This method produces mainly cyclohexylamine with little dicyclohexylamine.
Phenylhydroxylamine is the organic compound with the formula C 6 H 5 NHOH. It is an intermediate in the redox-related pair C 6 H 5 NH 2 and C 6 H 5 NO. Phenylhydroxylamine should not be confused with its isomer α-phenylhydroxylamine or O -phenylhydroxylamine.
In organic chemistry, hydroformylation, also known as oxo synthesis or oxo process, is an industrial process for the production of aldehydes (R−CH=O) from alkenes (R 2 C=CR 2). This chemical reaction entails the net addition of a formyl group (−CHO) and a hydrogen atom to a carbon-carbon double bond.
Synthesis. An early synthesis of phenylethanolamine was by the reduction of 2-nitro-1-phenyl-ethanol. Other early syntheses are summarized in a paper by Hartung and Munch. A more recent synthesis, providing a better yield, is by the reduction of benzoyl cyanide using LiAlH 4. Properties
In planning the synthesis of phenylacetic acid, two synthons are identified: a nucleophilic "COOH −" group, and an electrophilic "PhCH 2 +" group. Of course, both synthons do not exist by themselves; synthetic equivalents corresponding to the synthons are reacted to produce the desired reactant .