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Cyclohexylamine is used as an intermediate in synthesis of other organic compounds. It is the precursor to sulfenamide -based reagents used as accelerators for vulcanization. It is a building block for pharmaceuticals (e.g., mucolytics, analgesics, and bronchodilators ).
History. Phencyclidine (PCP) is believed to be the first arylcyclohexylamine with recognized anesthetic properties, but several arylcyclohexylamines were described before PCP in the scientific literature, beginning with PCA (1-phenylcyclohexan-1-amine) the synthesis of which was first published in 1907. PCP itself was discovered in 1926 but not ...
Eticyclidine ( PCE, CI-400) is a dissociative anesthetic drug with hallucinogenic effects. It is similar in effects to phencyclidine but is slightly more potent. PCE was developed by Parke-Davis in the 1970s and evaluated for anesthetic potential under the code name CI-400, [2] but research into PCE was not continued after the development of ...
Synthesis. Dicyclohexylamine, as a mixture with cyclohexylamine, is prepared by the catalytic hydrogenation of aniline (phenylamine), with a catalyst of ruthenium and/or palladium. This method produces mainly cyclohexylamine with little dicyclohexylamine.
The pyrolysis of N,N-dimethyl-2-phenylcyclohexylamine-N-oxide shows how conformational effects and the stability of the transition state affect product composition for cyclic substrates. In the trans isomer, there are two cis-β-hydrogens that can eliminate. The major product is the alkene that is in conjugation with the phenyl ring, presumably ...
Synthesis. One method for preparing β-phenethylamine, set forth in J. C. Robinson and H. R. Snyder's Organic Syntheses (published 1955), involves the reduction of benzyl cyanide with hydrogen in liquid ammonia, in the presence of a Raney-Nickel catalyst, at a temperature of 130 °C and a pressure of 13.8 MPa. Alternative syntheses are outlined ...
Synthesis. An early synthesis of phenylethanolamine was by the reduction of 2-nitro-1-phenyl-ethanol. Other early syntheses are summarized in a paper by Hartung and Munch. A more recent synthesis, providing a better yield, is by the reduction of benzoyl cyanide using LiAlH 4. Properties
A chemical synthesis involves one or more compounds (known as reagents or reactants) that will experience a transformation when subjected to certain conditions. Various reaction types can be applied to formulate a desired product.
Ether synthesis by reaction of salicylaldehyde with chloroacetic acid and sodium hydroxide. The Williamson ether synthesis is an organic reaction, forming an ether from an organohalide and a deprotonated alcohol . This reaction was developed by Alexander Williamson in 1850.
Synthesis. There are many routes to synthesize phenylacetone. Industry uses the gas-phase ketonic decarboxylation of phenylacetic acid using acetic acid over a ceria-alumina solid acid catalyst. A related laboratory-scale reaction has been described. An alternative route is zeolite-catalyzed isomerization of phenylpropylene oxide.